Deadline has reported that Netflix has released a trailer for the streamer’s upcoming limited series Painkiller. The series stars Matthew Broderick (Ferris Bueller’s Day Off, No Hard Feelings) and Uzo Aduba (Orange Is the New Black, In Treatment) and is about the role of Purdue Pharma in the origins of the opiood crisis.

Broderick stars as Richard Sackler, senior executive at Purdue Pharma and scion of the billionaire Sackler family. Aduba plays an investigator leading the case against Purdue Pharma, Eddie.

The cast also includes West Duchovny (A Mouthful of Air, The Report), Taylor Kitsch (Friday Night Lights, True Detective), and Dina Shihabi (Tom Clancy’s Jack Ryan, Altered Carbon).

The series is based on the novel Pain Killer by Barry Meier (Missing Man, Spooked: The Secret Rise of Private Spies) and the Patrick Radden Keefe (Say Nothing, The Snakehead) article  “The Family That Built an Empire of Pain” in the New Yorker Magazine. It explores the origins and aftermath of the opioid crisis in America.

Painkiller highlights the stories of victims, truth-seekers, and perpetrators whose lives were forever changed by the invention of OxyContin. It is an examination of accountability, crime, and the systems that have repeatedly failed hundreds of thousands of Americans.

The series was created by Noah Harpster (For All Mankind One Mississippi) and Micah Fitzerman-Blue (Maleficent: Mistress of Evil, A Beautiful Day in the Neighborhood), who serve as showrunners. Pete Berg (Prime Suspect, Friday Night Lights) directs all episodes and executive produces along with Fitzerman-Blue, Harpster, Alex Gibney (Dirty Money, Parched), and Eric Newman (The Watcher, Narcos).

According to Deadline, in an interview with Netflix’s Tudum, Newman said that the story continues to be urgently relevant, “The story is still going on. It’s playing out in real time, and I imagine that it will continue to play out long after us. It’s a story that’s so big and so awful that it deserves to be told as often and as loudly as it can be.”

Check out the trailer for Painkiller below.