Michelle Monaghan is set to star in the HBO drama pilot Open, Deadline has learned.

The Fox 21 project from Ryan Murphy and Lauren Gussis is described as a modern, provocative exploration of human sexuality and relationships. Monaghan will play lead female character Grace, a successful and recently engaged gynecologist.

Scott Speedman will play Grace’s fiancé Jonathan. Other cast members include Wes Bently, Anna Torv and Jennifer Jason Leigh.

Monaghan is repped by ICM Partners, Circle of Confusion and attorney Robert Offer. Her upcoming works include Fort Bliss, A Many Splintered Thing and Better Living Through Chemistry.