Well-known network comedy creator Chuck Lorre is bringing another series, B Positive, to CBS with a past collaborator, Marco Pennette. Additionally, actor Thomas Middleditch will take on the series’ lead role, according to Deadline. The upcoming CBS pilot is a comedy series will revolve around a divorced father Drew (Middleditch) searching for a kidney until he encounters Gina, who fills in as a potential donor.

In addition to Middleditch’s casting, the series also includes Annaleigh Ashford (Masters of Sex) as Gina, Kether Donohue (You’re the Worst), and Sara Rue (Less Than Perfect). The pairing of Lorre and Pennette with comedy actor Middleditch on a new network comedy has given network audiences high expectations for the impending comedy. 

Lorre and Pennette currently work as collaborators on CBS’s ongoing successful comedy, Mom, while also involving themselves in separate projects. Pennette was an executive producer and one of the showrunners for ABC’s successful series, Ugly Betty. Lorre, for the past three decades, has created, written, and directed various CBS series such as Two and a Half Men, The Big Bang Theory, Mike & Molly, and Young Sheldon, additionally winning a Golden Globe award for Netflix’s The Kominsky Method in 2019.

Middleditch’s addition to the cast as the series’ main character re-introduces him as the face for another comedy series in front of a new network audience. The actor has numerous film credits under his belt such as supporting roles in 2010’s The Other Guys, 2012’s The Campaign and 2013’s The Wolf of Wall Street in addition to a line of television roles. The majority of audiences recognize Middleditch for his portrayal of the awkward coder turned CEO of Pied Pier Richard Hendricks in HBO’s successful comedy, Silicon Valley. Created by Mike Judge (Beavis and Butt-Head and King of the Hill), the series depicts the complex tech world and the individuals that compose its environment. The show concluded its run after six seasons in the fall of 2019. 

The closing of Silicon Valley’s door has seemingly led to the opening of another for Middleditch. Despite the announcement of its cast and creators, CBS has not released the pilot’s premiere date. Regardless, the reveal of another Lorre and Pennette comedy for CBS partnered with established comedy actors, Middleditch, Ashford, Donohue, and Rue, has prompted much of excitement about B Positive’s potential.