Prime Video Reveals Key Art and Official Trailer For Season Two Of ‘The Second Best Hospital In The Galaxy’

Prime Video recently released key art and the official trailer for season two of The Second Best Hospital in the Galaxy. Eight episodes are set to debut exclusively on Prime Video on Tuesday, May 27, 2025, in more than 240 countries and territories across the world.
According to Prime Video, The Second Best Hospital in the Galaxy “follows daring surgeons (and inseparable best friends) Dr. Sleech and Dr. Klak, where they frequently risk everything to take on the most dangerous cases in the universe. In Season Two of The Second Best Hospital in the Galaxy, doctors Sleech and Klak relish the fame of their recent success until a cyborg journalist starts digging a little too deep into Sleech’s past.”

Here are the first-look images of the series that Prime Video has released.

According to Prime Video, season two of The Second Best Hospital in the Galaxy is created by Cirocco Dunlap (Russian Doll, Everything is Okay). Dunlap is also credited as showrunner, executive producer and writer. The show is executively produced by Maya Rudolph (Bridesmaids, Saturday Night Live), Natasha Lyonne (Orange is the New Black, American Pie) and Danielle Renfrew Behrens (Night Comes On, Lucky) for Animal Pictures, Shannon Prynoski (Her, Big Mouth), Chris Prynoski (Motorcity, Downtown), Shauna McGarry (Tuca & Bertie, Katy Keene), Antonio Canobbio (Pantheon, Scavengers Reign), and Ben Kalina (Big Mouth, Kiff) from Titmouse. Prime Video also states that Artist and animator Robin Eisenberg will co-produce and serve as production designer.

Prime Video lists the show’s cast as Stephanie Hsu (Everything Everywhere All at Once, The Path), Keke Palmer (One of Them Days, Nope), Kieran Culkin (A Real Pain, Succession), Sam Smith (Spectre), Maya Rudolph (Loot, Bridesmaids), and Natasha Lyonne (Poker Face, American Pie). The series also features Tracee Ellis Ross (American Fiction, Black-ish), Abbi Jacobson (Broad City, Disenchantment), Andrew Dismukes (Saturday Night Live, Call Me Brother), Bowen Yang (Saturday Night Live, Fire Island), Gary Anthony Williams (Night Court, Batman: Caped Crusader), Lennon Parham (Minx, Playing House), Jay Ellis (Top Gun: Maverick, Insecure), Kemah Bob (Springleaf, Fully Blown), and John Waters (Hairspray, 2:22).

Jorge Arreola: My name is Jorge Arreola. I am 21 years old and I'm currently in my third year attending California State University Northridge. I am currently pursuing a degree in Journalism. I have lived in the Los Angeles county my whole life. I've always had a feel for writing but I never realized it until my first few years in high school. It was then where I made up my mind to pursue a career in journalism.
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