Seth MacFarlane has brought audiences over-the-top moments in comedy with shows like Family Guy and films like A Million Ways to Die in the West, and has also shown his passion for the world of science by providing Cosmos: a Spacetime Odyssey with the financial support necessary to bring the show to broadcast television, which gave views the chance to delve into the mysteries of the universe with host Neil deGrasse Tyson. Now, MacFarlane is bringing the worlds of comedy and science together in a new live-action Fox sci-fi dramedy.

According to Deadline, the new series will be set 300 years in the future and center around the crew of the Orville, an exploratory vehicle for the people of the earth that isn’t exactly top of the line. MacFarlane will act as series lead and captain of the Orville as it embarks  on a journey into the outer reaches of space. Think a little bit of Star Trek, a little bit of Firefly, some classic MacFarlane comedy, and most likely a vaudeville number or two. MacFarlane is joined by female lead Adrianne Palicki (Agents of S.H.I.E.L.D.), Scott Grimes (American Dad), Peter Macon (Shameless), and former Cleveland Show writer J. Lee. Lee is also working with MacFarlane on another Fox series, 2 Black Dudes, which Lee will star in and MacFarlane will produce.

MacFarlane has also signed on Jon Favreau, the director behind the first two Iron Man films, and most recently The Jungle Book, to direct the first episode of Orville. Favreau will stay on as a consultant and executive producer.

Orville has a straight-to-series order from Fox and is expected to have a 13 episode season. Production is set to begin in January.